A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease
Identifieur interne : 001676 ( Main/Exploration ); précédent : 001675; suivant : 001677A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease
Auteurs : Evelien Huisman [Pays-Bas] ; Harry B. M. Uylings [Pays-Bas] ; Piet V. Hoogland [Pays-Bas, Afrique du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-06.
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Abstract
Hyposmia is one of the most prevalent symptoms of Parkinson's disease. It may occur even before the motor symptoms start. To determine whether the olfactory dysfunctions, like the motor symptoms, are associated with a loss of dopamine, the number of dopaminergic cells in the olfactory bulb of Parkinson's disease patients was studied using tyrosine hydroxylase immunohistochemistry. The quantitative analysis reveals that the total number of tyrosine hydroxylase–immunoreactive neurons in the olfactory bulb is twice as high in Parkinson patients compared to age and gender‐matched controls. Because dopamine is known to inhibit olfactory transmission in the olfactory glomeruli, we suggest that the increase of dopaminergic neurons in the olfactory bulb is responsible for the hyposmia in Parkinson patients. The increase of dopamine in the olfactory bulb explains why olfaction does not improve with levodopa therapy. © 2004 Movement Disorder Society
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DOI: 10.1002/mds.10713
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-06">2004-06</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="687">687</biblScope><biblScope unit="page" to="692">692</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DD2F8F69612F085C9DC63928285D2B60FF7B84A6</idno><idno type="DOI">10.1002/mds.10713</idno><idno type="ArticleID">MDS10713</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson</term><term>dopamine</term><term>hyposmia</term><term>immunohistochemistry</term><term>olfactory bulb</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hyposmia is one of the most prevalent symptoms of Parkinson's disease. It may occur even before the motor symptoms start. To determine whether the olfactory dysfunctions, like the motor symptoms, are associated with a loss of dopamine, the number of dopaminergic cells in the olfactory bulb of Parkinson's disease patients was studied using tyrosine hydroxylase immunohistochemistry. The quantitative analysis reveals that the total number of tyrosine hydroxylase–immunoreactive neurons in the olfactory bulb is twice as high in Parkinson patients compared to age and gender‐matched controls. Because dopamine is known to inhibit olfactory transmission in the olfactory glomeruli, we suggest that the increase of dopaminergic neurons in the olfactory bulb is responsible for the hyposmia in Parkinson patients. The increase of dopamine in the olfactory bulb explains why olfaction does not improve with levodopa therapy. © 2004 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Huisman, Evelien" sort="Huisman, Evelien" uniqKey="Huisman E" first="Evelien" last="Huisman">Evelien Huisman</name></region><name sortKey="Hoogland, Piet V" sort="Hoogland, Piet V" uniqKey="Hoogland P" first="Piet V." last="Hoogland">Piet V. Hoogland</name><name sortKey="Uylings, Harry B M" sort="Uylings, Harry B M" uniqKey="Uylings H" first="Harry B. M." last="Uylings">Harry B. M. Uylings</name><name sortKey="Uylings, Harry B M" sort="Uylings, Harry B M" uniqKey="Uylings H" first="Harry B. M." last="Uylings">Harry B. M. Uylings</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Hoogland, Piet V" sort="Hoogland, Piet V" uniqKey="Hoogland P" first="Piet V." last="Hoogland">Piet V. Hoogland</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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